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GSK343 br During cardiac ischaemia a decrease in GJ coupling
2022-01-03
During cardiac ischaemia, a decrease in GJ coupling is observed, which results in slower conduction of electrical impulses and a higher risk of arrhythmias.[13], [20] In Huntington’s disease an increase in the GSK343 of 5 Cxs was observed in the astrocytes in the brain, suggesting an adaptive prot
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br Introduction The fibroblast growth factor receptor FGFR p
2022-01-03
Introduction The fibroblast growth factor receptor (FGFR) pathway is an important oncogenic driver in malignant cancer. It controls cellular processes such as cell proliferation, differentiation, migration, trpv1 progression, metabolism, and survival. In non–small-cell lung cancer, the most freq
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We detected the FFAR protein with a molecular
2022-01-03
We detected the FFAR2 protein with a molecular mass of about 50 kDa, which is comparable to the main band detected in pigs (Li et al., 2014) but different from the calculated size based on the sequence (Wang et al., 2009). The size difference can be explained, at least in part, by glycosylation site
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br Results and discussion CATALYST
2022-01-03
Results and discussion CATALYST software allows automatic pharmacophore construction by using a collection of molecules with activities ranging over a number of orders of magnitude. In addition, CATALYST pharmacophores (hypotheses) explain the variability of bioactivity with respect to the geomet
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The release of FBPase and aldolase from subcellular structur
2022-01-03
The release of FBPase and aldolase from subcellular structures of muscle was dependent on the presence of the crowding agent imitating the physiological conditions – PEG 8000 (Table 1). The amount of both enzymes associated with structures of muscle ikk pathway was about 6–7 times higher in the pres
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Drosophila is a well established model to investigate the
2022-01-03
Drosophila is a well-established model to investigate the molecular and cellular defects underlying human neurodevelopmental disorders (Oortveld et al., 2013, van der Voet et al., 2014). Here, we establish Drosophila as a model for understanding the mechanisms linking mutations in KDM5 family protei
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ICLs represent of all generated DNA adducts for cisplatin an
2022-01-03
ICLs represent ICL Inducers in Cancer Therapy Nitrogen mustards with aromatic substituents (chlorambucil, melphalan) or a bioactivatable phosphoramide group (cyclophosphamide) were one of the first identified DNA crosslinkers. These agents are still used in combined schemes for the therapy of chr
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During embryogenesis the expression of zGpr was found higher
2021-12-31
During embryogenesis, the expression of zGpr84 was found higher at the cleavage stage and decreased at both blastula and gastrula stages. It indicates that maternal zGpr84 transcripts are present at the cleavage and blastula stages, since zygotic transcripts are not produced before the gastrula stag
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It is important to clarify whether the
2021-12-31
It is important to clarify whether the decrease in USV after administration was secondary to the central depressant actions of the test compounds. Several reports have addressed the possibility that central depressant actions such as motor incoordination or changes in body temperature might affect U
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br Materials and Methods br Results br Discussion
2021-12-31
Materials and Methods Results Discussion A model of seizure and excitotoxicity induced by neonatal MSG administration was described recently (19) in which extracellular glutamate increased after the first and second MSG administrations were observed, the greatest increase seen following the
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Injury to oligodendrocyte progenitors caused in part by glut
2021-12-31
Injury to oligodendrocyte progenitors caused in part by glutamate contributes to the pathogenesis of myelination disturbances in PVL [5]. In the immature human brain, the susceptibility of developing oligodendrocytes to hypoxia-ischemia correlates with their expression of glutamate receptors of the
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The plasma levels of glucose and
2021-12-31
The plasma levels of glucose and amino acids at day 0 likely represent the function in utero since the blood was collected within 2h after birth. To elucidate the roles of intestinal transporters as determinants of plasma levels of glucose and amino acids, we analyzed the correlation between the exp
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br Glucose metabolism and diet Glucokinase is essential
2021-12-31
Glucose metabolism and diet Glucokinase is essential for sensing blood glucose levels, thus controls metabolism (Iynedjian, 1993, Iynedjian, 2009, Postic et al., 2001, Agius, 2008). Loss of glucokinase activity in humans and mice leads to diabetes (Printz et al., 1993b, Postic et al., 2001, Agius
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Some other neuroinflammatory neuroendocrine and
2021-12-31
Some other neuroinflammatory, neuroendocrine, and neurotrophic pathway but not the ghrelin/GHSR pathway may mediate the CUMS-induced depression- and anxiety-like behaivors. The endogeous ghrelin/GHSR pathway activated by chronic mild stress may plays a role in homeostasis. With respect to the mechan
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The role of cell to
2021-12-30
The role of cell-to-cell interactions in coordinating the cells’ behaviour to ensure an appropriate anterior pituitary hormone response is receiving increasing attention. Anterior pituitary R-848 synthesis interact with neighbouring cells through junctional complexes. As their name implies, the comp
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