• Some aspects of intercellular Ca wave spread

  2022-05-31

  

  Some aspects of intercellular Ca2+ wave spread are similar to the phenomenon of spreading depression and associated with migraine headache [57]. These depolarization waves, followed by electrical inhibition, are evoked by transient hypoxia and other types of SB 747651A dihydrochloride injury and sp

• Our previous study had shown that silencing FFAR

  2022-05-30

  

  Our previous study had shown that silencing FFAR1 expression weakened the action of PIO in increasing insulin secretion in lipotoxic β hydroxypropyl beta cyclodextrin mg [6]. Resent research found that PIO promoted insulin secretion by upregulating FFAR1 [17]. Therefore, we presumed that FFAR1 may b

• Furthermore rs is the one

  2022-05-30

  

  Furthermore, rs17171119 is the one which is studied well so far. One of the earlier studies has reported the clinical outcome and impact of EZH2 SNPs (rs41277434, rs3757441, rs2302427 rs9177211 T> C) (Crea et al., 2012). The only coding SNP ID rs2302427 has been studied in various diseases such as h

• br Histamine H R The

  2022-05-30

  

  Histamine H4R The cloning of the H3R (Lovenberg et al., 1999) provided a template for the search of other sesamin mg receptors, and resulted in the most recent discovery of histamine H4R. This concluded with six independent groups that have reported the cloning of the H4R (Leurs et al., 2009, Li

• Aberrant expression of HKII may be a required feature for

  2022-05-30

  

  Aberrant expression of HKII may be a required feature for cancer development and progression. Overexpression of HKII has been reported in tumor tissues of cancer patients with liver [9], ovary [8], [24] and larynx [25]. The clinical significance of HKII in cancer was noted as overexpression of HKII

• br Notch Similar to the Wnt and Hedgehog

  2022-05-30

  

  Notch Similar to the Wnt and Hedgehog pathways as discussed earlier, Notch is an evolutionarily conserved primordial developmental pathway which affects patterning, and has an important role to play in cancer biology ranging from angiogenesis to cancer stem CBiPES hydrochloride to tumor immunity

• The urinary levels of OHP among the exposed workers were

  2022-05-30

  

  The urinary levels of 1-OHP among the exposed workers were higher than those reported for a Brazilian group of charcoal workers (0.07 μmol mol creatinine) exposed to wood smoke (Kato et al., 2004), and for nonsmoking bus drivers (0.19 μmol mol creatinine) and nonsmoking mail carriers (0.11 μmol mol

• br Medium and long chain fatty acid receptors

  2022-05-30

  

  Medium- and long-chain fatty Folinic acid receptors Clinical studies of ω3 fatty acids Clinical studies have established that dietary intake of ω3 fatty acids should be around 4g/day for treating very high triglyceride levels (≥5.7mmol/L) [36]. Low-dose supplementation with EPA + DHA (400mg/da

• Waldeck Weiermair et al demonstrated that in endothelial cel

  2022-05-30

  

  Waldeck-Weiermair et al. (2008) demonstrated that in endothelial cells, the activation of GPR55 by application of 10µM anandamide resulted in a marked increase of ERK1/2 phosphorylation that was evident 2min following drug activation and was sustained for up to 3h. Another example comes from our unp

• br Funding M I is supported

  2022-05-30

  

  Funding M.I. is supported by European Research Council (ERC) Consolidator Grant 725038, Italian Association for Cancer Research (AIRC) Grant 19891, Italian Ministry of Health (MoH) Grant GR-2011-02347925, Lombardy Foundation for Biomedical Research (FRRB) Grant 2015-0010, the European Molecular B

• The use of HIV peptide epitope

  2022-05-30

  

  The use of HIV-1 peptide epitope-based vaccines is safer and cheaper than live or inactivated vaccines [8]. However, peptide epitope vaccines could show poor immunogenicity and have poor uptake by APCs [9]. Nevertheless, nanocarrier-based delivery platforms have been demonstrated to enhance the pept

• To further investigate if GPR was the functional target of

  2022-05-30

  

  To further investigate if GPR40 was the functional target of these phenylpropiolic Rosiglitazone maleate analogs, GW-1100, a selective antagonist of GPR40-mediated Ca2+ elevations in HEK293 cells with an IC50 value equal to 1 μM, was used to inhibit agonist-induced intracellular calcium flux [15]. H

• The synthesis of compounds and were achieved according to st

  2022-05-27

  

  The synthesis of compounds and were achieved according to standard procedures. As shown in , The compound 4-methyl-1-(4-sulfobutyl)quinolonium () was prepared by alkylation reaction. Compounds and were synthesized by substitution reactions between 4-fluorobenzaldehyde and , , '-trimethylethanedi

• verapamil hydrochloride br Materials and methods br

  2022-05-27

  

  Materials and methods Results Discussion FFAR4 is a G-protein coupled free fatty verapamil hydrochloride receptor that has been reported to be expressed in osteoclasts and osteoblasts [18]. In this study the role of FFAR4 on the effects of different classes of UFAs, the ω−6 PUFA, AA, the ω

• A great number of proteins entering the nucleus

  2022-05-27

  

  A great number of proteins entering the nucleus possess a characteristic nuclear localization sequence (NLS) in their primary structure. One of such sequences is the KKKGK motif [30]. It is present in all known muscle (but not liver – except human liver) FBPase sequences (human, rabbit, rat and mous

15074 records 427/1005 page Previous Next First page 上5页 426427428429430 下5页 Last page