• A few methods have been developed to separate and prepare

  2022-07-21

  

  A few methods have been developed to separate and prepare compounds from L. chinensis, such as silica gel column chromatography [5,6] and high-performance liquid chromatography (HPLC) [7]. Silica gel column chromatography is still used for its simple equipment and low cost. However, this method is o

• In recent years several DPP IV

  2022-07-21

  

  In recent years, several DPP-IV inhibitors have already been approved, such as sitagliptin, vildagliptin, saxagliptin, tenegliptin, alogliptin and linagliptin, etc. Among them, linagliptin (1, Fig. 1) is a non-peptide mimetic Thiorphan with a unique xanthine scaffold developed through high-throughp

• The rat model was validated with another agonist

  2022-07-21

  

  The rat model was validated with another agonist of GPR109A, acipimox. Acipimox has been shown to induce vasodilatation in man, by a mechanism dependent on the release of vasodilator prostaglandins (Edlund et al., 1990, Pontiroli et al., 1992). Acipimox is a weaker agonist of the GPR109A receptor (L

• As preclinical toxicity and efficacy both appear to be

  2022-07-21

  

  As preclinical toxicity and efficacy both appear to be associated with GlyT1 inhibition, it remains to be determined whether on-target toxicity can be separated from efficacy. The present study evaluated a series of GlyT1 inhibitors for target potency, mode of inhibition, residence time, activity in

• IBs had a clear vesicular

  2022-07-21

  

  IBs had a clear vesicular ultrastructure, suggesting that a large part of the iron-containing mitochondrial remnants might be cleared via normal autophagy processes during final reticulocyte maturation [21]. IB formation was followed by characteristic changes in RBC morphology, with irregularly shap

• br Method br Results br Discussion There were

  2022-07-21

  

  Method Results Discussion There were two major sources of fluorescent signals of NADH in the mouse retina. One was a product derived from glutamate and the other was the elevation of intrinsic NADH. In the present study, we observed significant contamination from intrinsic NADH in “the oute

• br Vesicular glutamate transporters VGLUTs br Conclusions Du

  2022-07-21

  

  Vesicular glutamate transporters (VGLUTs) Conclusions Due to the molecular cloning of EAAT and VGLUT subtypes, a better understanding of the functional properties of these carriers has been elucidated over the last few years. In the case of the EAATs, specific blockers, such as trans-2,4-PDC,

• Rhapontigenin australia br Materials and methods br

  2022-07-21

  

  Materials and methods Results Discussion In the CNS, GLP-1R is associated with G-protein signal transduction pathways, which can activate adenylyl cyclase and protein kinase A by cyclic adenosine monophosphate, and mediates neuronal activities implicated in various pathophysiological change

• The genes for the receptors for peptides similar

  2022-07-21

  

  The genes for the receptors for peptides similar to glucagon are dispersed on three human chromosomes, with two on chromosome 17 (GCGR and GLP2R) and one each on chromosomes 6 (GLP1R) and 19 (GIPR) (see Table S1). The exon–intron gene structures of these genes are similar, as are the genes for other

• Insulin de sensitization has been observed in the brains

  2022-07-21

  

  Insulin de-sensitization has been observed in the brains of people with AD [51], [52], [53] and we previously demonstrated that the GLP-1 analogue liraglutide was able to reverse this [54]. Importantly, pgds inhibitor insulin de-sensitization correlates well with cognitive decline [15], [55] and wit

• In the liver ghrelin has opposite effects to insulin on

  2022-07-21

  

  In the liver, ghrelin has opposite effects to insulin on the expression of the enzyme PEPCK, thereby promoting gluconeogenesis and also causing a decrease in glucose uptake and fatty mek inhibitor oxidation (Rigault et al., 2007). Ghrelin also stimulates hepatic lipogenesis de novo in a GH-independ

• The galactosidase from Aspergillus oryzae is a monomeric enz

  2022-07-21

  

  The β-galactosidase from Aspergillus oryzae is a monomeric enzyme of 113 kDa [58] that has been widely used in GOS synthesis [49,53,[59], [60], [61]], exhibiting a high activity of lactose transgalactosylation [62]. Different immobilization methods have been used for the synthesis of lactose-derived

• A mutation in stearoyl coenzyme A

  2022-07-21

  

  A mutation in stearoyl coenzyme A desaturase 1 gene was reported to reduce sebum production and monounsaturated fatty acids (MUFA) synthesis in mice, which was accompanied with impaired clearance of gram-positive bacteria-induced skin infection (Georgel et al., 2005). Interestingly, gram-positive ba

• All data were analyzed using SAS

  2022-07-21

  

  All data were analyzed using SAS software (version 9.3, SAS Institute Inc., Cary, NC). Because of very low FFAR1 protein detection (at the detection limit or no signal) in 3 H-BHB cows, quantification was not possible within a linear range and therefore these animals were omitted from the statistica

• Introduction Osteoclasts are large multinuclear cells that

  2022-07-21

  

  Introduction Osteoclasts are large, multinuclear Cefepime Dihydrochloride Monohydrate that are responsible for the resorption (breakdown) of bone [1]. Together with osteoblasts, the bone forming cell, they maintain the integrity of the skeleton through constant resorption and repair of bone. Osteo

15061 records 396/1005 page Previous Next First page 上5页 396397398399400 下5页 Last page