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br Parkinson s Disease and the immune system Parkinson s
2025-01-03
Parkinson’s Disease and the immune system Parkinson’s Disease (PD) is the second most common neurodegenerative disorder, after Alzheimer’s, which affects 10 million people globally and is characterized by rigidity, bradykinesia, tremors, and gait instability (O’sullivan et al., 2007). The patholo
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Clindamycin HCl The results also showed that the A receptor
2025-01-03
The results also showed that the A3 receptor agonist increased the phosphorylated levels of Akt, leading to activation of the PI3K/Akt pathway. A3 Clindamycin HCl stimulation has protective effects against RGC death following ischemia-reperfusion, glutamate toxicity, and optic nerve transection mod
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br Results br Discussion The present study
2025-01-03
Results Discussion The present study uncovers a role of calpain, a family of calcium-dependent protease, in regulating postsynaptic differentiation at the NMJ. Cholinergic activation stimulates calpain, whose inhibition stabilizes AChR clusters in cultured muscle MMAE in apoptosis induction an
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br Discussion The clinical course of our patient until May
2025-01-03
Discussion The clinical course of our patient until May 2012 was rather typical of early onset AChR-MG. Later on, the pattern of the disease was more typical of MuSK-MG, as evidenced by the distribution of myasthenic weakness and the unprovoked exacerbations. The 4a 5 2 3.25 a of MuSK-MG appears
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The indirect effect of corporate taxation as given
2025-01-03
The indirect effect of corporate taxation, as given by the second term in Eq. (18), consists of two elements; (i) a standard Otamixaban effect (τ/n2), and (ii) a capital cost effect (rG(1−αt)/(1−t)). With a CRS technology, the cost effect vanishes, whereas with an IRS (a DRS) technology the cost ef
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In humans the major LOs are subdivided by their positional
2025-01-03
In humans, the major LOs are subdivided by their positional specificity into 5-(ALOX5), 12-(ALOX12) and 15-LO (ALOX15) (Kuhn et al., 2015). 5-LO is the key enzyme for LT biosynthesis and mainly found in mature cells from myeloid origin, including neutrophil, eosinophil and basophil granulocytes, mon
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br Acknowledgements br Introduction Thus damage to the nervo
2025-01-02
Acknowledgements Introduction Thus, damage to the histone demethylation may produce severe consequences (National Research Council, 1992). Indeed, though the nervous system has several compensatory and adaptive mechanisms, it is vulnerable to toxic insult, due to its inability to regenerate a
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In liver the essential organ of
2025-01-02
In liver, the essential organ of lipoprotein synthesis, ACL plays a fundamental role in lipogenesis and steroidogenesis by supplying cytosolic bicuculline to both pathways. By using a tricarboxylic acid cycle intermediate (citrate) to produce acetyl CoA, ACL can be seen as an important bridge betwe
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br APJ expression in metabolic
2025-01-02
APJ expression in metabolic diseases Under physiological conditions, APJ is present in humans as well as in mouse tissues with high metabolic activity such as muscle and adipose tissue but not in the liver. Moreover, the presence and regulation of APJ in established adipocyte or muscle cell lines
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Besides the described changes in protein expression and
2025-01-02
Besides the described changes in protein expression and thus in current amplitudes, BCECF-AM of PORCN also leads to accelerated decay kinetics of evoked and spontaneous AMPAR currents. These changes in channel kinetics are most likely a secondary effect due to the selective depletion of γ-8 but not
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br Author Contributions br Acknowledgments br Introduction C
2025-01-02
Author Contributions Acknowledgments Introduction Cerebral ischemia-reperfusion (I/R) injury is a pathological phenomenon that occurs after restoration of blood supply to HU 308 tissues subsequent to ischemia or hypoxia (Carden and Granger, 2000). It typically occurs after therapeutic throm
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br Materials and methods br Discussion Few
2024-12-31
Materials and methods Discussion Few studies have examined peripheral PACAP levels in migraineurs, and no reports have described PACAP levels in blood samples from patients with CM. Here, we demonstrated that plasma PACAP concentrations were lower in patients with interictal migraine (in both
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br Acknowledgements This work was supported by grants
2024-12-31
Acknowledgements This work was supported by grants from the Program for Changjiang Scholars and Innovative Research Team in University (IRT_14R28), the National Basic Research Program of China (973) (Grant No.: 2013CB733602), the Major Research Plan of the National Natural Science Foundation of C
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br Concluding remarks br Definition Prion diseases
2024-12-30
Concluding remarks Definition Prion diseases are fatal neurodegenerative disorders that are caused by an unconventional agent that is neither bacterial nor viral, but is in essence an infectious misfolded amyloidogenic protein, termed a prion (Prusiner, 1982). Once considered highly controvers
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roflumilast moa Testosterone can be converted into estrogens
2024-12-30
Testosterone can be converted into estrogens by aromatase action. Aromatase is encoded by CYP19, belongs to cytochrome P450 superfamily, and synthesizes estradiol (E2) and estrone (E1) from testosterone and androstenedione respectively (Fig. 1). Aromatase is expressed in the ORS of anagen hair folli
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